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Together with the German Federal Institute for Materials Research and Testing (BAM), Merete Medical GmbH has developed EPICAL™, a new patented procedure for generating bioactive, calcium-rich implant surfaces. EPICAL™ modifies the surfaces of permanent titanium or titanium-alloy implants (and endoprostheses) to provide optimal bone adhesion. Years of cooperative research work led to the discovery that titanium's and titanium alloy's (TiO2) natural passivation layers can be chemically converted to calcium titanate (CaTiO3) without coating.

Since the end of October 2011, Merete Medical GmbH has held CE certification from the notified certification body, MedCert, to apply the procedure to the cementless implantation of the anatomically formed Merete Merotan™ hip-stem.

The EPICAL™ technology creates a calcium-rich reaction zone to a depth of up to ca. 50 nm, meaning it does not constitute a coating. The advantage of the procedure lies in the fact that it creates osteoinductive surfaces which release calcium ions when they come into contact with bodily fluids. These calcium ions then penetrate into the surrounding bone tissue and help stimulate bone growth.

The "Germany - Land of Ideas" Initiative named EPICAL™ their 2009 Product of the Year.

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